Linda Collins
Linda M. Collins, PhD
CDUHR - Co-Director, Transdisciplinary Research Methods Core
NYU School of Global Public Health - Professor
NYU School of Global Public Health - Director, Intervention Optimization Initiative
PhD, Quantitative Psychology, University of Southern California
BA, Psychology, University of Connecticut
Research Interests
HIV, Multiphase optimization strategy (MOST), Experimental design, Research methods, Substance use, Prevention, Intervention science, Cancer prevention and control
Linda Collins’s interests are focused on development, dissemination, and application of the multiphase optimization strategy (MOST), an engineering-inspired methodological framework for optimizing and evaluating behavioral, biobehavioral, and social-structural interventions. The objective of MOST is to improve intervention effectiveness, affordability, scalability, and efficiency, balancing these strategically to achieve intervention EASE.  Dr. Collins has collaborated on research applying MOST in a range of areas, including HIV, smoking cessation, prevention of sexually transmitted infections, and weight loss. She is also collaborating on development of methods for optimizing interventions for cost-effectiveness, and on improvement of methods for optimization of adaptive interventions.  Her research has been funded by NIDA, NIAAA, NCI, NIDDK, and NSF. Dr. Collins’s publications have appeared in journals in the behavioral science, methodology, medicine, and engineering fields.  She is a Fellow of the American Psychological Association, the Association for Psychological Science, the Society for Prevention Research, and the Society of Behavioral Medicine, and has been President of the Society of Multivariate Experimental Psychology and the Society for Prevention Research.  Among the honors she has received are a Fulbright Specialist grant, the President’s Award from the Society for Prevention Research, and the 2020 Valkhov Chair from Radboud University Medical Centre in The Netherlands.
Principal Investigator, Optimized Chronic Care for Smokers: Developing and Implementing Integrated Clinical and Systems Intervention in Primary Care – Optimization Core. Active
Principal Investigator, Using MOST to Optimize an HIV Care Continuum Intervention for Vulnerable Populations. Active


Strayhorn JC, Collins LM, Brick TR, Marchese SH, Pfammatter AF, Pellegrini C, Spring B (2022).
Using factorial mediation analysis to better understand the effects of interventions
Translational Behavioral Medicine, 12 (1), ibab137. doi: 10.1093/tbm/ibab137. PMCID: PMC8764990.

Qian T, Walton AE, Collins LM, Klasnja P, Lanza ST, Nahum-Shani I, Rabbi M, Russell MA, Walton MA, Yoo H, Murphy SA (2022).
The microrandomized trial for developing digital interventions: Experimental design and data analysis considerations
Psychological Methods [Epub 2022 Jan 13]. doi: 10.1037/met0000283.

Tanner AE, Guastaferro KM, Rulison KL, Wyrick DL, Milroy JJ, Bhandari S, Thorpe S, Ware S, Miller AM, Collins LM (2021).
A hybrid evaluation-optimization trial to evaluate an intervention targeting the intersection of alcohol and sex in college students and simultaneously test an additional component aimed at preventing sexual violence
Annals of Behavioral Medicine, 55 (12), 1184-1187. doi: 10.1093/abm/kaab003. PMCID: PMC8601044.

He N, Cleland CM, Gwadz M, Sherpa D, Ritchie AS, Martinez BY, Collins LM (2021).
Understanding medical distrust among African American/Black and Latino persons living with HIV with sub-optimal engagement along the HIV care continuum: A machine learning approach
SAGE Open, 11 (4). doi: 10.1177/21582440211061314.

Collins LM, Strayhorn JC, Vanness DJ (2021).
One view of the next decade of research on behavioral and biobehavioral approaches to cancer prevention and control: intervention optimization
Translaional Behavioral Medicine, 11 (11), 1998-2008. doi: 10.1093/tbm/ibab087. PMCID: PMC8634530.


Collins LM (2018).
Optimization of behavioral, biobehavioral, and biomedical interventions: The multiphase optimization strategy (MOST).
New York: Springer. ISBN: 978-3-319-72205-4.

Collins LM, Kugler KC (Eds.) (2018).
Optimization of behavioral, biobehavioral, and biomedical interventions: Advanced topics.
New York: Springer. ISBN: 978-3-319-91775-7.

Collins LM, Kugler KC, Gwadz MV (2016).
Optimization of multicomponent behavioral and biobehavioral interventions for the prevention and treatment of HIV/AIDS
AIDS and Behavior, 20 (Suppl 1), 197-214. doi: 10.1007/s10461-015-1145-4. PMCID: PMC4715714.

Dr. Collins' Google Scholar Profile