ResearchProjects

The Subthreshold Opioid Use Disorder Prevention (STOP) Trial is an innovative study of early intervention to prevent opioid use disorder.  STOP, a primary care-based collaborative care intervention attempted to reduce opioid use and overdose risk, and prevent progression to the more severe condition of opioid use disorder, in adult patients who have risky use of illicit or prescription opioids.  This national study, conducted within the NIDA Clinical Trials Network (CTN) in five primary care sites, tested the efficacy of STOP versus enhanced usual care.