Randomized Controlled Trial of Relay – NYC’s Nonfatal Overdose Response Program
Funded by: National Center for Injury Prevention and Control, CDC
Project dates: September 2019 - September 2022
Principal Investigator: Doran, Kelly
Principal Investigator: McNeely, Jennifer
Co-Investigator: Cowan, Ethan (Site PI)
Co-Investigator: Gwadz, Marya
Co-Investigator: Cleland, Charles

This study evaluated the impact of Relay, a peer navigator-led secondary overdose prevention intervention, on reducing subsequent opioid-related – fatal and nonfatal – events.

Eligible individuals with nonfatal opioid overdose presenting at one of four participating emergency departments were enrolled and randomized to either: enhanced usual care (overdose education and naloxone distribution and list of opioid treatment programs; or to Relay, a peer-delivered overdose education and treatment linkage, including 90 days of peer navigation.

This study advances the science of overdose prevention and can inform programs and policies for emergency department-based interventions for secondary prevention of opioid overdose.

Abstract on NIH RePORTER
Related Publications
Doran KM, Welch AE, Jeffers A, Kepler KL, Chambless D, Cowan E, Wittman I, Regina A, Chang TE, Parraga S, Tapia J, Diaz C, Gwadz M, Cleland CM, McNeely J (2023).
Study protocol for a multisite randomized controlled trial of a peer navigator intervention for emergency department patients with nonfatal opioid overdose
Contemporary Clinical Trials, 126, 107111. doi: 10.1016/j.cct.2023.107111.