ResearchProjects

Addressing Hepatitis C and Hepatocellular Carcinoma: The Current and Future Epidemics
Funded by: National Institute on Drug Abuse
Project dates: July 2013 - April 2018
Principal Investigator: Hagan, Holly
Co-Investigator: Braithwaite, Scott
Co-Investigator: Des Jarlais, Don
PROJECT DESCRIPTION

Hepatitis C virus (HCV) infection is present in an estimated 150–200 million people worldwide and HCV is hyper-endemic among people who inject drugs (PWID).  In addition, outbreaks of HCV have recently occurred among HIV-positive men who have sex with men (MSM) and in adolescents and young adults who have transitioned from prescription opiate misuse to drug injection. In patients with chronic HCV infection, 20-25% will develop liver disease which may manifest as cirrhosis, liver failure or hepatocellular carcinoma (HCC), the most common type of liver cancer. The study estimated the effects of prevention and treatment interventions, alone and in combination, on the HCV disease burden in PWID and HIV+MSM. The results of the study is be used to guide public health policy and resource allocation to control HCV infection in the US and other countries.

Abstract on NIH RePORTER
Related Publications
Khan B, Duncan I, Saad M, Schaefer D, Jordan A, Smith D, Neaigus A, Des Jarlais D, Hagan H, Dombrowski K (2018).
Combination interventions for hepatitis C and cirrhosis reduction among people who inject drugs: An agent-based, networked population simulation experiment
PLoS One, 13 (11), e0206356. doi: 10.1371/journal.pone.0206356. PMCID: PMC6264850.

Jordan AE, Perlman DC, Smith DJ, Reed JR, Hagan H (2018).
Use of the PRECIS-II instrument to categorize reports along the efficacy-effectiveness spectrum in an hepatitis C virus care continuum systematic review and meta-analysis
Journal of Clinical Epidemiology, 93, 66-75. doi: 10.1016/j.jclinepi.2017.10.015. PMCID: PMC5767157.

Jordan AE, Perlman DC, Reed J, Smith DJ, Hagan H (2017).
Patterns and gaps identified in a systematic review of the hepatitis C virus care continuum in studies among people who use drugs
Frontiers in Public Health, 5, 348. doi: 10.3389/fpubh.2017.00348. PMCID: PMC5741609.

Platt L, Minozzi S, Reed J, Vickerman P, Hagan H, French C, Jordan A, Degenhardt L, Hope V, Hutchinson S, Maher L, Palmateer N, Taylor A, Bruneau J, Hickman M (2017).
Needle syringe programmes and opioid substitution therapy for preventing hepatitis C transmission in people who inject drugs
Cochrane Database of Systematic Reviews, 9, CD012021. doi: 10.1002/14651858.CD012021.pub2. PMCID: PMC5621373.

Smith DJ, Neurer J, Jordan AE, Hagan H (2017).
Epidemiology of hepatitis C virus among people who inject drugs: Protocol for a systematic review and meta-analysis
JMIR Research Protocols, 6 (10), e201. doi: 10.2196/resprot.7936. PMCID: PMC5670319.

Jordan AE, Blackburn NA, Des Jarlais DC, Hagan H (2017).
Past-year prevalence of prescription opioid misuse among those 11 to 30 years of age in the United States: A systematic review and meta-analysis
Journal of Substance Abuse Treatment, 77, 31-37. doi: 10.1016/j.jsat.2017.03.007. PMCID: PMC5699231.

Jordan AE, Perlman DC, Neurer J, Smith DJ, Des Jarlais DC, Hagan H (2017).
Prevalence of hepatitis C virus infection among HIV+ men who have sex with men: A systematic review and meta-analysis
International Journal of STD and AIDS, 28 (2), 145-159. doi: 10.1177/0956462416630910. PMCID: PMC4965334.

Reed JR, Jordan AE, Perlman DC, Smith DJ, Hagan H (2016).
The HCV care continuum among people who use drugs: Protocol for a systematic review and meta-analysis
Systematic Reviews, 5, 110. doi: 10.1186/s13643-016-0293-6. PMCID: PMC4940695.

Smith DJ, Jordan AE, Frank M, Hagan H (2016).
Spontaneous viral clearance of hepatitis C virus (HCV) infection among people who inject drugs (PWID) and HIV-positive men who have sex with men (HIV+ MSM): A systematic review and meta-analysis
BMC Infectious Diseases, 16, 471. doi: 10.1186/s12879-016-1807-5. PMCID: PMC5011802.

Combellick J, Smith DJ, Jordan AE, Hagan H (2015).
Hepatitis C virus disease progression in people who inject drugs: Protocol for a systematic review and meta-analysis
JMIR Research Protocols, 4 (2), e68. doi: 10.2196/resprot.4518. PMCID: PMC4526911.

Hagan H, Jordan AE, Neurer J, Cleland CM (2015).
Incidence of sexually transmitted hepatitis C virus infection in HIV-positive men who have sex with men
AIDS, 29 (17), 2335-2345. doi: 10.1097/QAD.0000000000000834. PMCID: PMC4640945.

Khan B, Dombrowski K, Curtis R, Wendel T (2015).
Estimating vertex measures in social networks by sampling completions of RDS trees
Social Networking, 4 (1), 1-6. doi: 10.4236/sn.2015.41001. PMCID: PMC4380167.

Smith DJ, Combellick J, Jordan AE, Hagan H (2015).
Hepatitis C virus (HCV) disease progression in people who inject drugs (PWID): A systematic review and meta-analysis
International Journal of Drug Policy, 26 (10), 911-921. doi: 10.1016/j.drugpo.2015.07.004. PMCID: PMC4577462.

Jordan AE, Des Jarlais DC, Hagan H (2014).
Prescription opioid misuse and its relation to injection drug use and hepatitis C virus infection: Protocol for a systematic review and meta-analysis
Systematic Reviews, 3, 95. doi: 10.1186/2046-4053-3-95. PMCID: PMC4158728.

Hagan H, Neurer J, Jordan AE, Des Jarlais DC, Wu J, Dombrowski K, Khan B, Braithwaite RS, Kessler J (2014).
Hepatitis C virus infection among HIV-positive men who have sex with men: Protocol for a systematic review and meta-analysis
Systematic Reviews, 3, 31. doi: 10.1186/2046-4053-3-31. PMCID: PMC3986916.