ResearchProjects

The Subthreshold Opioid Use Disorder Prevention (STOP) Trial is an innovative study of early intervention to prevent opioid use disorder.  STOP is a primary care-based collaborative care intervention to reduce opioid use and overdose risk, and prevent progression to the more severe condition of opioid use disorder, in adult patients who have risky use of illicit or prescription opioids.  This national study, conducted within the NIDA Clinical Trials Network (CTN) in five primary care sites, will test the efficacy of STOP versus enhanced usual care.