Peer-Driven Intervention to Enroll Minorities/Women in HIV/AIDS Clinical Trials (ACT2)
Funded by: National Institute of Allergy and Infectious Diseases
Project dates: May 2007 - April 2012
Principal Investigator: Gwadz, Marya
Co-Investigator: Cleland, Charles
Co-Investigator: Leonard, Noelle

Racial/ethnic minorities and women are disproportionately over-represented among those with HIV/AIDS in the U.S, yet they are under-represented in AIDS clinical trials (ACTs). This study evaluated the efficacy of a culturally targeted peer-driven intervention to improve ACT screening and enrollment rates among racial/ethnic minorities and women living with HIV/AIDS (PLHA). The intervention was comprised of three facilitated small-group sessions, and patient navigation through the screening process which facilitated access to screening for ACTs. The study was evaluated in a cluster randomized controlled trial design and compared to a typical health education program.  The study found that the intervention substantially increased rates of screening for ACTs, and 9 out of 10 of those found eligible for a medical study or trial enrolled in a study, mainly biomedical observational studies. The findings also have important implications for other health conditions for which racial/ethnic disparities persist in clinical trials, and other types of medical research, including HCV, cancer, and HIV vaccine research.

Abstract on NIH RePORTER
Related Publications
Gwadz M, Cleland CM, Belkin M, Ritchie A, Leonard N, Riedel M, Banfield A, Colon P, Elharrar V, Kagan J, Mildvan D (2014).
ACT2 peer-driven intervention increases enrollment into HIV/AIDS medical studies among African Americans/Blacks and Hispanics: A cluster randomized controlled trial
AIDS and Behavior, 18 (12), 2409-2422. doi: 10.1007/s10461-014-0829-5. PMCID: PMC4451823.

Gwadz M, Cleland CM, Leonard NR, Ritchie AS, Banfield A, Riedel M, Colon P, Mildvan D (2013).
Predictors of screening for AIDS clinical trials among African-Americans and Latino/Hispanics enrolled in an efficacious peer-driven intervention: Uncovering socio-demographic, health, and substance use-related factors that promote or impede screening
AIDS and Behavior, 17 (2), 801-812. doi: 10.1007/s10461-012-0194-1. PMCID: PMC4181555.

Leonard NR, Banfield A, Riedel M, Ritchie AS, Mildvan D, Arredondo G, Cleland CM, Gwadz MV (2013).
Description of an efficacious behavioral peer-driven intervention to reduce racial/ethnic disparities in AIDS clinical trials
Health Education Research, 28 (4), 574-590. doi: 10.1093/her/cyt052. PMCID: PMC3708137.

Gwadz MV, Leonard NR, Cleland CM, Riedel M, Banfield A, Mildvan D (2011).
The effect of peer-driven intervention on rates of screening for AIDS clinical trials among African Americans and Hispanics
American Journal of Public Health, 101 (6), 1096-1102. doi: 10.2105/AJPH.2010.196048. PMCID: PMC3093288.

Gwadz MV, Colon P, Ritchie AS, Leonard NR, Cleland CM, Riedel M, Bowens D, Banfield AD, Chang P, Quiles R, Mildvan D (2010).
Increasing and supporting the participation of persons of color living with HIV/AIDS in AIDS clinical trials
Current HIV/AIDS Reports, 7 (4), 194-200. doi: 10.1007/s11904-010-0055-3. PMCID: PMC3634564.