Benefits and Harms of Lung Cancer Screening in HIV Infection
Funded by: National Cancer Institute
Project dates: April 2013 - March 2019
Principal Investigator: Braithwaite, R. Scott
Principal Investigator: Crothers K
Principal Investigator: Wisnivesky J

Lung cancer is the most common non-AIDS defining cancer (NADC) and leading source of NADC mortality amongst HIV infected (HIV+) individuals. Unfortunately, most lung cancers are diagnosed at an advanced stage and have low 5-year survival rates and earlier detection strategies are urgently needed. Previous research has shown that low-dose screening chest computed tomography (CT) scans may be helpful but the research was only done with high-risk HIV (HIV-) uninfected smokers. These results may not be as useful for HIV+ individuals since they often experience other illnesses and risks, and are also more likely to have false positive CT scans. This study developed a mathematical model that will help improve knowledge regarding the use of CT scans for HIV+ high-risk smokers.  The analyses will help improve the estimates of the potential benefits of screening for HIV+ high-risk smokers, identify the appropriate candidates for screening, and determine the best screening regimen. Information from the study will help guide better screening recommendations and improved care for HIV+ smokers.

Abstract on NIH RePORTER