ResearchProjects

ED-EXACT in Opioid Overdose: Emergency Department Evaluation of Xylazine-Associated Clinical Toxicity in Opioid Overdose
Funded by: National Institute on Drug Abuse
Project dates: February 2026 - January 2031
Principal Investigator: Love, Jennifer
PROJECT DESCRIPTION

The project will develop and refine a clinical registry for emergency department opioid overdose patients exposed to xylazine and novel adulterants. The registry will integrate health records, toxicologic, serum biomarkers and clinical outcomes data.

Using qualitative interviews with people who use drugs and addiction medicine specialists, the registry’s data elements and outcomes will be refined to reflect meaningful, targeted data collection

Study aims include:

  1. Creating a clinical registry for xylazine-associated overdose and comprehensive ED care;
  2. Measuring xylazine and its metabolites in serum/blood and urine using laboratory and point-of-care assays; and
  3. Refining registry data elements and outcomes using perspectives of individuals with knowledge of xylazine and adulterants
Abstract on NIH RePORTER